I’ll start here with Kill Six Billion Demons, by Abaddon, an ongoing series that covers the adventures of Allison, a college student thrust into greatness. With insanely good art, and an amazing story and hecka neat world building, this is my current favorite webcomic!
Have a sample, wherein our heroine is engaged in a drinking contest with a demon:
Edit: I forgot to mention, K6BD updates Tuesday and Friday evenings (and occasionally weekends). Abaddon also takes audience suggestions on background characters.