I don’t use it regularly for my tabletop RPG group, but I recently used Tabletop Simulator to run a weird session of my current campaign based loosely off of Hand of Fate. I essentially used a tarot deck as a sort of group improv generator to set up some scenes. In general, Tabletop Simulator can seem a bit gimmicky on the surface, but the feel of moving objects with physics in a virtual space gives it an appeal that other online mapping software doesn’t have and genuinely adds a lot to the experience. I’d like to use it more in the future.
That said, most of what I use Tabletop Simulator for now is playing Solitaire. I might have weird tastes. 